Crafting Everything

Ancestry-adjusted Hardy–Weinberg testing

Accounting for population structure in variant quality control
population-genetics
bioinformatics
statistics

How principal components and individual-specific allele frequencies let RUTH test for HWE departures after accounting for ancestry and genotype uncertainty.

Sep 24, 2026

Hardy–Weinberg and the Wahlund effect

Why pooling populations creates a heterozygote deficit
population-genetics
bioinformatics
statistics

What an excess of Hardy–Weinberg QC failures led me to learn about population structure, with an interactive explainer.

Sep 19, 2026

Extracting Room Boundaries from 3D Scans

Python
computational-geometry
3D-reconstruction

Using RANSAC and NDT-RANSAC to detect walls from iPhone photogrammetry scans and extract clean floor plan polygons.

Jan 18, 2026

Making My Own Engagement Ring

jewelry-making
DIY
I always knew I wanted to make my own engagement ring – even before I was sure that it was possible. It wasn’t just about the challenge (although I do have a habit of…
Feb 14, 2025

Automate Your Linux Desktop: Switching GTK Themes Based on Time of Day

Linux

Using systemd timers to automatically switch between light/dark GTK themes in a GNOME desktop.

Apr 24, 2020

Getting Book Prices from AbeBooks.com

Reverse Engineering a REST API
Python
API
books

Often, we encounter the need to extract data from websites that lack publicly documented REST APIs. In this post, I demonstrate how to analyze POST and GET requests from AbeBooks.com using a browser and build a Python API wrapper to programmatically retrieve book prices and recommendations.

Apr 10, 2020

Interweaving R and Python with Reticulate and Apache Arrow

Python
Rstats
dataviz

Combining Python’s powerful data processing with R’s rich data visualization and statistical libraries.

May 4, 2019

Mapping Pharos Targets with Structures

Python
cheminformatics
dataviz

Using SIFTS’ UniProt-PDB mappings, we identify NIH Pharos targets with known ligand binding affinities and at least one Protein Data Bank structure.

Feb 14, 2019
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